Computational and Translational Neuroscience Laboratory

CTNLab uses an interdisciplinary approach to do neuroscience research and to translate it into clinical applications and novel therapies for nervous system disorders.

The ultimate aim is to translate the advances in neuroscience into benefits for patients.

Alzheimer’s disease

ADHD

artificial Intelligence

Ataxia

autism

Big data

Computational Psychiatry

Depression

Dynamic causal modelling

Digital twin

machine learning

Parkinson’s disease

Personalised Medicine

Precision Medicine

Computational Neuroscience

Additional info

Profile

Methodological approach.

Investigating multiple levels of brain complexities by combining two complementary approaches:

Theory-driven approaches which use computational models that instantiate explicit hypotheses about brain functions at multiple levels of analysis (from circuit to behavioral level).
Data-driven approaches which apply artificial intelligence and machine learning methods to high dimensional data to improve classification of disease, predict treatment outcomes or improve treatment selection.

These modelling approaches are integrated with empirical results of behavioral and neurophysiological experiments as well as with clinical and imaging data. Advanced neuroimaging analyses (MVPA, DCM, DTI) could be also used to test theoretical predictions.

Lab network facilities.

Imaging techniques (e.g., Policlinico Umberto I, Fondazione Santa Lucia), motion capture systems (e.g., University of Genova), neurophysiology (e.g., Campus Bio-Medico).

https://ctnlab.it/

Coordinators

Daniele Caligiore

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Massimo Silvetti

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Members

Pierandrea Mirino (PhD student)

Chiara Ponte (PhD student)

Adriano Capirchio (Postgraduate trainee)

Flora Giocondo (Postgraduate trainee)

Francesco Montedori (Postgraduate trainee)

Members

Publications

Contributo in volume

2020

Towards an Agent-Based Model for the Analysis of Macroeconomic Signals

Platas-Lopez A., Guerra-Hernandez A., Cruz-Ramirez N., Quiroz-Castellanos M., Grimaldo F., Paolucci M., Cecconi F.

Source: Intuitionistic and Type-2 Fuzzy Logic Enhancements in Neural and Optimization Algorithms: Theory and Applications., edited by Castillo,Oscar. Melin, Patricia. Kacprzyk,Janusz., pp. 551–565. Cham, Heidelberg, New York, Dordrecht, London: Springer, 2020, info:cnr-pdr/source/autori:Platas-Lopez A.; Guerra-Hernandez A.; Cruz-Ramirez N.; Quiroz-Castellanos M.; Grimaldo F.; Paolucci M.; Cecconi F./titolo:Towards an Agent-Based Model for the Analysis of Macroeconomic Signals/titolo_volume:Intuitionistic and Ty

2019

A Computational Hypothesis on How Serotonin Regulates Catecholamines in the Pathogenesis of Depressive Apathy

Massimo Silvetti, Gianluca Baldassarre, Daniele Caligiore

Source: Multiscale Models of Brain Disorders, edited by Cutsuridis V., pp. 127–134. Cham, Heidelberg, New York, Dordrecht, London: Springer, 2019, info:cnr-pdr/source/autori:Massimo Silvetti, Gianluca Baldassarre, Daniele Caligiore/titolo:A Computational Hypothesis on How Serotonin Regulates Catecholamines in the Pathogenesis of Depressive Apathy/titolo_volume:Multiscale Models of Brain Disorders/cu

The development of reaching and grasping: towards an integrated framework based on a critical review of computational and robotic models

Caligiore Daniele and Baldassarre Gianluca

Source: Reach-to-Grasp Behavior: Brain, Behavior, and Modelling Across the Life Span, edited by Corbetta Daniela and Santello Marco. Abingdon: Routledge Journals, Taylor & Francis Ltd., 2019, info:cnr-pdr/source/autori:Caligiore Daniele and Baldassarre Gianluca/titolo:The development of reaching and grasping: towards an integrated framework based on a critical review of computational and robotic models/titolo_volume:Reach-to-Grasp Behavior: Br

Articolo

2019

Action Observation With Dual Task for Improving Cognitive Abilities in Parkinson's Disease: A Pilot Study

Caligiore, Daniele, Mustile, Magda, Fineschi, Alissa, Romano, Laura, Piras, Fabrizio, Assogna, Francesca, Pontieri, Francesco E., Spalletta, Gianfranco, Baldassarre, Gianluca

Source: Frontiers in systems neuroscience 13 (2019): 7. doi:10.3389/fnsys.2019.00007, info:cnr-pdr/source/autori:Caligiore, Daniele and Mustile, Magda and Fineschi, Alissa and Romano, Laura and Piras, Fabrizio and Assogna, Francesca and Pontieri, Francesco E. and Spalletta, Gianfranco and Baldassarre, Gianluca/titolo:Action Observation Wit

Different dopaminergic dysfunctions underlying parkinsonian akinesia and tremor

Caligiore Daniele, Mannella Francesco, Baldassarre Gianluca

Source: Frontiers in neuroscience (Online) 13 (2019). doi:10.3389/fnins.2019.00550, info:cnr-pdr/source/autori:Caligiore Daniele, Mannella Francesco, Baldassarre Gianluca/titolo:Different dopaminergic dysfunctions underlying parkinsonian akinesia and tremor/doi:10.3389/fnins.2019.00550/rivista:Frontiers in neuroscience (Online)/anno:201

The Morphology of Somatosensory evoked potentials during middle cerebral artery Aneurysm Clipping: a pilot study

franca tecchio, federico cecconi, luca valci, matteo padalino, elisabetta colamartino

Source: Clinical EEG and neuroscience 2 (2019)., info:cnr-pdr/source/autori:franca tecchio, federico cecconi, luca valci, matteo padalino, elisabetta colamartino/titolo:The Morphology of Somatosensory evoked potentials during middle cerebral artery Aneurysm Clipping: a pilot study/doi:/rivista:Clinical

The super-learning hypothesis: Integrating learning processes across cortex, cerebellum and basal ganglia

Caligiore D., Arbib M.A., Miall R.C., Baldassarre G.

Source: Neuroscience and biobehavioral reviews 100 (2019): 19–34. doi:10.1016/j.neubiorev.2019.02.008, info:cnr-pdr/source/autori:Caligiore D.; Arbib M.A.; Miall R.C.; Baldassarre G./titolo:The super-learning hypothesis: Integrating learning processes across cortex, cerebellum and basal ganglia/doi:10.1016/j.neubiorev.2019.02.008/rivista:Neuroscience and b

2017

Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome

Caligiore Daniele, Mannella Francesco, Arbib Michael A., Baldassarre Gianluca

Source: PLOS computational biology (Online) 13 (2017). doi:10.1371/journal.pcbi.1005395, info:cnr-pdr/source/autori:Caligiore Daniele, Mannella Francesco, Arbib Michael A., Baldassarre Gianluca/titolo:Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome/doi:10.1371/journal.pcbi.1005395/

The architecture challenge: Future artificial-intelligence systems will require sophisticated architectures, and knowledge of the brain might guide their construction

Baldassarre Gianluca, Santucci Vieri Giuliano, Cartoni Emilio, Caligiore Daniele

Source: Behavioral and brain sciences (Online) 40 (2017). doi:10.1017/S0140525X17000036, info:cnr-pdr/source/autori:Baldassarre Gianluca, Santucci Vieri Giuliano, Cartoni Emilio, Caligiore Daniele/titolo:The architecture challenge: Future artificial-intelligence systems will require sophisticated architectures, and knowledge of the brain migh

2016

A reinforcement learning architecture that transfers knowledge between skills when solving multiple tasks

Paolo Tommasino, Daniele Caligiore, Marco Mirolli, Gianluca Baldassarre

Source: IEEE Transactions on Cognitive and Developmental Systems (2016). doi:10.1109/TCDS.2016.2607018, info:cnr-pdr/source/autori:Paolo Tommasino ; Daniele Caligiore ; Marco Mirolli ; Gianluca Baldassarre/titolo:A reinforcement learning architecture that transfers knowledge between skills when solving multiple tasks/doi:10.1109/TCDS.2016.2607018/rivista:IE

Action observation and motor imagery for rehabilitation in Parkinson's disease: A systematic review and an integrative hypothesis.

Caligiore, Daniele, Mustile, Magda, Spalletta, Gianfranco, Baldassarre, Gianluca

Source: Neuroscience and biobehavioral reviews 72 (2016): 210–222. doi:10.1016/j.neubiorev.2016.11.005, info:cnr-pdr/source/autori:Caligiore, Daniele; Mustile, Magda; Spalletta, Gianfranco; Baldassarre, Gianluca/titolo:Action observation and motor imagery for rehabilitation in Parkinson's disease: A systematic review and an integrative hypothesis./doi:10.10

Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex

Caligiore D., Pezzulo G., Baldassarre G., Bostan A.C., Strick P.L., Doya K., Helmich R.C., Dirkx M., Houk J., Jorntell H., Lago-Rodriguez A., Galea J.M., Miall R.C., Popa T., Kishore A., Verschure P.F.M.J., Zucca R., Herreros I.

Source: Cerebellum (Lond., Print) 16 (2016): 203–229. doi:10.1007/s12311-016-0763-3, info:cnr-pdr/source/autori:Caligiore D.; Pezzulo G.; Baldassarre G.; Bostan A.C.; Strick P.L.; Doya K.; Helmich R.C.; Dirkx M.; Houk J.; Jorntell H.; Lago-Rodriguez A.; Galea J.M.; Miall R.C.; Popa T.; Kishore A.; Verschure P.F.M.J.; Zucca R.; Herreros I.

Interplay of rhythmic and discrete manipulation movements during development: a policy-search reinforcement-learning robot model

Meola Valentina Cristina, Caligore Daniele, Sperati Valerio, Zollo Loredana, Ciancio Anna Lisa, Taffoni Fabrizio, Guglielmelli Eugenio, Baldassarre Gianluca

Source: IEEE Transactions on Cognitive and Developmental Systems 8 (2016): 152–170. doi:10.1109/TAMD.2015.2494460, info:cnr-pdr/source/autori:Meola Valentina Cristina, Caligore Daniele, Sperati Valerio, Zollo Loredana, Ciancio Anna Lisa, Taffoni Fabrizio, Guglielmelli Eugenio, Baldassarre Gianluca/titolo:Interplay of rhythmic and discrete manipulation movements during

Mispricing and Price Overreaction

Federico Cecconi

Source: Research in applied economics (2016)., info:cnr-pdr/source/autori:Federico Cecconi/titolo:Mispricing and Price Overreaction/doi:/rivista:Research in applied economics/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:

Contributo in atti di convegno

2019

Micro-foundations of macroeconomic dynamics: The agent-based BAM model

Platas-Lopez A., Guerra-Hernandez A., Cecconi F., Paolucci M., Grimaldo F.

Source: 22nd International Conference of the Catalan Association for Artificial Intelligence, 23-25/10/2019, info:cnr-pdr/source/autori:Platas-Lopez A.; Guerra-Hernandez A.; Cecconi F.; Paolucci M.; Grimaldo F./congresso_nome:22nd International Conference of the Catalan Association for Artificial Intelligence/congresso_luogo:/congresso_data:23-25/10/2019/anno:20

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Additional info

Coordinatore

Coordinatore

Technician

2020

2019

2019

2017

2016

2019