99mTc-HMPAO distribution at SPECT is associated with succinate-cytochrome c reductase (SCR) activity in subjects with psychiatric disorders

The origin of altered 99mTc-HMPAO distribution at SPECT in psychiatric disorders is unknown. Correlations between brain 99m
Tc-HMPAO distribution and muscle succinate-cytochrome c reductase (SCR, complex II III) were assessed in 20 unmedicated psychiatric
patients. Significant negative correlations were found between 99mTc-HMPAO distribution in associative sensory regions and SCR activity.
Sensory cortices are normally enriched in complex II activity. The production of electrons and reactive oxygen species affecting the redox
state is considered to be highest from complex III, but complex II may also contribute. The negative relationship between 99mTc-HMPAO
uptake and SCR activity may be due to redox state alterations influencing fixation of the radiopharmaceutical.

Tipo Pubblicazione: 
Articolo
Author or Creator: 
Gardner A.
Pagani M.
Beier
H.
Larsson
S.A.
Hallstrom
T.
Publisher: 
Pergamon Press,, New York , Regno Unito
Source: 
Nuclear medicine and biology 31 (2004): 277–282.
info:cnr-pdr/source/autori:Gardner A., Pagani M., Beier, H., Larsson, S.A., Hallstrom, T./titolo:99mTc-HMPAO distribution at SPECT is associated with succinate-cytochrome c reductase (SCR) activity in subjects with psychiatric disorders/doi:/rivista:Nucle
Date: 
2004
Resource Identifier: 
http://www.cnr.it/prodotto/i/47059
Language: 
Eng
ISTC Author: 
Ritratto di Marco Pagani
Real name: