Laboratory of Electrophysiology for Translational neuroScience | Istituto di Scienze e Tecnologie della Cognizione

LET’S (Laboratory of Electrophysiology for Translational neuroScience)–CNR operates, after 18 years at Fatebenefratelli Hospital, in the Gemelli Hospital in Rome.

LET'S operates with magneto- and electro‑encephalo- and myo-graphy (MEG, EEG, EMG) and non-invasive neuromodulation techniques (tES - tDCS, tACS, tIDS- and TMS) that modify neuronal electrical activity. Let’s develops methods of brain complexity analysis and therapeutic interventions via precision Electroceuticals.

Additional info

Profile

The key fields of investigation are:

Precision Electroceuticals (Top10Tech by World Economic Forum 2018)
personalized neuromodulation, home treatments, clinical biomarkers, tailored therapy, telemedicine, hybrid technology, wearable communication devices,
electrophysiology, magneto- and electro-encephalography and electromyography (MEG, EEG, EMG), fractal dimension, Functional Source Separation (FSS), feedback-synchrony-plasticity, morphology,
transcranial magnetic and electric stimulation (TMS, tES with transcranial Individual neuroDynamics Stimulation, tIDS),
fatigue, stroke, depression, multiple sclerosis, epilepsy.

Technology

128 EEG BP actiCHamp and polygraphic channel system (Brain Products, Germany)
Interactive Pressure Sensor (InPresS) developed in-House on Arduino board
tDCS stimulators (2 BrainSTIM, EMS srl, Italy)
TMS SuperRapid Stimulator (Magstim, Germany)
Neuronavigation system composed of a position sensor, made of the IR Polaris Vicra optical tracking unit, equipped with SofTaxic software (EMS srl, Bologna, Italy)
Software suites for advanced signal processing and statistics.

Members

Coordinatore

Franca Tecchio

Publications

Articolo

2019

Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery

Zappasodi, Filippo, Pasqualetti, Patrizio, Rossini, Paolo M., Tecchio, Franca

Source: Neural Plasticity (Print) 2019 (2019). doi:10.1155/2019/1971875, info:cnr-pdr/source/autori:Zappasodi, Filippo; Pasqualetti, Patrizio; Rossini, Paolo M.; Tecchio, Franca/titolo:Acute Phase Neuronal Activity for the Prognosis of Stroke Recovery/doi:10.1155/2019/1971875/rivista:Neural Plasticity (Print)/anno:2019/pagina_

Cortical neurodynamics changes mediate the efficacy of a personalized neuromodulation against multiple sclerosis fatigue

Porcaro, Camillo, Cottone, Carlo, Cancelli, Andrea, Rossini, Paolo M., Zito, Giancarlo, Tecchio, Franca

Source: Scientific reports (Nature Publishing Group) 9 (2019). doi:10.1038/s41598-019-54595-z, info:cnr-pdr/source/autori:Porcaro, Camillo; Cottone, Carlo; Cancelli, Andrea; Rossini, Paolo M.; Zito, Giancarlo; Tecchio, Franca/titolo:Cortical neurodynamics changes mediate the efficacy of a personalized neuromodulation against multiple sclerosis fati

Longitudinal quantitative electroencephalographic study in mono-hemispheric stroke patients

Zappasodi, Filippo, Tecchio, Franca, Marzetti, Laura, Pizzella, Vittorio, Di Lazzaro, Vincenzo, Assenza, Giovanni

Source: Neural Regeneration Research 14 (2019): 1237–1246. doi:10.4103/1673-5374.251331, info:cnr-pdr/source/autori:Zappasodi, Filippo; Tecchio, Franca; Marzetti, Laura; Pizzella, Vittorio; Di Lazzaro, Vincenzo; Assenza, Giovanni/titolo:Longitudinal quantitative electroencephalographic study in mono-hemispheric stroke patients/doi:10.4103/167

Neuronal dynamics enable the functional differentiation of resting state networks in the human brain

Marino, Marco, Liu, Quanying, Samogin, Jessica, Tecchio, Franca, Cottone, Carlo, Mantini, Dante, Porcaro, Camillo.

Source: Human brain mapping (Print) (2019). doi:10.1002/hbm.24458, info:cnr-pdr/source/autori:Marino, Marco; Liu, Quanying; Samogin, Jessica; Tecchio, Franca; Cottone, Carlo; Mantini, Dante; Porcaro, Camillo./titolo:Neuronal dynamics enable the functional differentiation of resting state networks in the human brain/doi:1

The Morphology of Somatosensory evoked potentials during middle cerebral artery Aneurysm Clipping: a pilot study

franca tecchio, federico cecconi, luca valci, matteo padalino, elisabetta colamartino

Source: Clinical EEG and neuroscience 2 (2019)., info:cnr-pdr/source/autori:franca tecchio, federico cecconi, luca valci, matteo padalino, elisabetta colamartino/titolo:The Morphology of Somatosensory evoked potentials during middle cerebral artery Aneurysm Clipping: a pilot study/doi:/rivista:Clinical

2018

A New, High-Efficacy, Noninvasive Transcranial Electric Stimulation Tuned to Local Neurodynamics

Cottone, Carlo, Cancelli, Andrea, Pasqualetti, Patrizio, Porcaro, Camillo, Salustri, Carlo, Tecchio, Franca

Source: The Journal of neuroscience 38 (2018): 586–594. doi:10.1523/JNEUROSCI.2521-16.2017, info:cnr-pdr/source/autori:Cottone, Carlo; Cancelli, Andrea; Pasqualetti, Patrizio; Porcaro, Camillo; Salustri, Carlo; Tecchio, Franca/titolo:A New, High-Efficacy, Noninvasive Transcranial Electric Stimulation Tuned to Local Neurodynamics/doi:10.1523/JNEU

Brain Functional Connectivity Changes After Transcranial Direct Current Stimulation in Epileptic Patients

Tecchio, Franca, Cottone, Carlo, Porcaro, Camillo, Cancelli, Andrea, Di Lazzaro, Vincenzo, Assenza, Giovanni

Source: Frontiers in neural circuits 12 (2018). doi:10.3389/fncir.2018.00044, info:cnr-pdr/source/autori:Tecchio, Franca; Cottone, Carlo; Porcaro, Camillo; Cancelli, Andrea; Di Lazzaro, Vincenzo; Assenza, Giovanni/titolo:Brain Functional Connectivity Changes After Transcranial Direct Current Stimulation in Epileptic Patients/doi:10

Functional Semi-Blind Source Separation Identifies Primary Motor Area Without Active Motor Execution

Porcaro, Camillo, Cottone, Carlo, Cancelli, Andrea, Salustri, Carlo, Tecchio, Franca

Source: International journal of neural systems 28 (2018). doi:10.1142/S0129065717500472, info:cnr-pdr/source/autori:Porcaro, Camillo; Cottone, Carlo; Cancelli, Andrea; Salustri, Carlo; Tecchio, Franca/titolo:Functional Semi-Blind Source Separation Identifies Primary Motor Area Without Active Motor Execution/doi:10.1142/S0129065717500472/rivis

MRI-guided regional personalized electrical stimulation in multisession and home treatments

Cancelli, Andrea, Cottone, Carlo, Giordani, Alessandro, Asta, Giampiero, Lupoi, Domenico, Pizzella, Vittorio, Tecchio, Franca

Source: Frontiers in neuroscience (Print) 12 (2018). doi:10.3389/fnins.2018.00284, info:cnr-pdr/source/autori:Cancelli, Andrea; Cottone, Carlo; Giordani, Alessandro; Asta, Giampiero; Lupoi, Domenico; Pizzella, Vittorio; Tecchio, Franca/titolo:MRI-guided regional personalized electrical stimulation in multisession and home treatments/doi

Personalized, bilateral whole-body somatosensory cortex stimulation to relieve fatigue in multiple sclerosis

Cancelli, Andrea, Cottone, Carlo, Giordani, Alessandro, Migliore, Simone, Lupoi, Domenico, Porcaro, Camillo, Mirabella, Massimiliano, Rossini, Paolo Maria, Filippi, Maria Maddalena, Tecchio, Franca

Source: Multiple sclerosis 24 (2018): 1366–1374. doi:10.1177/1352458517720528, info:cnr-pdr/source/autori:Cancelli, Andrea; Cottone, Carlo; Giordani, Alessandro; Migliore, Simone; Lupoi, Domenico; Porcaro, Camillo; Mirabella, Massimiliano; Rossini, Paolo Maria; Filippi, Maria Maddalena; Tecchio, Franca/titolo:Personalized, bilateral

Prognostic value of serum copper for post-stroke clinical recovery: A pilot study

Squitti, Rosanna, Siotto, Mariacristina, Assenza, Giovanni, Giannantoni, Nadia M., Rongioletti, Mauro, Zappasodi, Filippo, Tecchio, Franca

Source: Frontiers in neurology 9 (2018). doi:10.3389/fneur.2018.00333, info:cnr-pdr/source/autori:Squitti, Rosanna; Siotto, Mariacristina; Assenza, Giovanni; Giannantoni, Nadia M.; Rongioletti, Mauro; Zappasodi, Filippo; Tecchio, Franca/titolo:Prognostic value of serum copper for post-stroke clinical recovery: A pilot study/

2017

Electroencephalography-Derived Sensory and Motor Network Topology in Multiple Sclerosis Fatigue

Vecchio, F., Miraglia, Porcaro, C., Cottone, Cancelli, A., Rossini, P.M., Tecchio

Source: Neurorehabilitation and neural repair 31 (2017): 56–64. doi:10.1177/1545968316656055, info:cnr-pdr/source/autori:Vecchio, F. and Miraglia, F. and Porcaro, C. and Cottone, C. and Cancelli, A. and Rossini, P.M. and Tecchio, F./titolo:Electroencephalography-Derived Sensory and Motor Network Topology in Multiple Sclerosis Fatigue/doi:10.1177/1

fMRI characterisation of widespread brain networks relevant for behavioural variability in fine hand motor control with and without visual feedback

Mayhew, Stephen D., Porcaro, Camillo, Tecchio, Franca, Bagshaw, Andrew P.

Source: NeuroImage (Orlando Fla., Print) 148 (2017): 330–342. doi:10.1016/j.neuroimage.2017.01.017, info:cnr-pdr/source/autori:Mayhew, Stephen D.; Porcaro, Camillo; Tecchio, Franca; Bagshaw, Andrew P./titolo:fMRI characterisation of widespread brain networks relevant for behavioural variability in fine hand motor control with and without visual feedback

Simple index of functional connectivity at rest in Multiple Sclerosis fatigue.

Buyukturkoglu, Korhan, Porcaro, Camillo, Cottone, Carlo, Cancelli, Andrea, Inglese, Matilde, Tecchio, Franca

Source: Clinical neurophysiology 128 (2017): 807–813. doi:10.1016/j.clinph.2017.02.010, info:cnr-pdr/source/autori:Buyukturkoglu, Korhan; Porcaro, Camillo; Cottone, Carlo; Cancelli, Andrea; Inglese, Matilde; Tecchio, Franca/titolo:Simple index of functional connectivity at rest in Multiple Sclerosis fatigue./doi:10.1016/j.clinph.2017.02.010/

Contributo in atti di convegno

2017

CATHODAL TRANSCRANIAL DIRECT CURRENT STIMULATION REDUCES SEIZURE FREQUENCY AND MODULATES BRAIN FUNCTIONAL CONNECTIVITY IN DRUG-RESISTANT TEMPORAL LOBE EPILEPSY: A SHAM CONTROLLED STUDY

Assenza, G., Cottone, C., Tecchio, F., Pellegrino, G., Campana, C., Porcaro, C., Cancelli, A., Assenza, F., Di Pino, G., Tombini, M., Di Lazzaro, V.

Source: 32nd International Epilepsy Congress, pp. S129–S130, Barcelona, SPAIN, 2017, info:cnr-pdr/source/autori:Assenza, G.; Cottone, C.; Tecchio, F.; Pellegrino, G.; Campana, C.; Porcaro, C.; Cancelli, A.; Assenza, F.; Di Pino, G.; Tombini, M.; Di Lazzaro, V./congresso_nome:32nd International Epilepsy Congress/congresso_luogo:Barcelona,

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