Laboratory of Electrophysiology for Translational neuroScience | Istituto di Scienze e Tecnologie della Cognizione

LET’S (Laboratory of Electrophysiology for Translational neuroScience)–CNR operates, after 18 years at Fatebenefratelli Hospital, in the Gemelli Hospital in Rome.

LET'S operates with magneto- and electro‑encephalo- and myo-graphy (MEG, EEG, EMG) and non-invasive neuromodulation techniques (tES - tDCS, tACS, tIDS- and TMS) that modify neuronal electrical activity, Let’s develops methods of brain complexity analysis and therapeutic interventions via precision Electroceuticals.

Additional info

Profile

The key fields of investigation are:

Precision Electroceuticals (Top10Tech by World Economic Forum 2018)
personalized neuromodulation, home treatments, clinical biomarkers, tailored therapy, telemedicine, hybrid technology, wearable communication devices,
electrophysiology, magneto- and electro-encephalography and electromyography (MEG, EEG, EMG), fractal dimension, Functional Source Separation (FSS), feedback-synchrony-plasticity, morphology,
transcranial magnetic and electric stimulation (TMS, tES with transcranial Individual neuroDynamics Stimulation, tIDS),
fatigue, stroke, depression, multiple sclerosis, epilepsy.

Technology

128 EEG BP actiCHamp and polygraphic channel system (Brain Products, Germany)
Interactive Pressure Sensor (InPresS) developed in-House on Arduino board
tDCS stimulators (2 BrainSTIM, EMS srl, Italy)
TMS SuperRapid Stimulator (Magstim, Germany)
Neuronavigation system composed of a position sensor, made of the IR Polaris Vicra optical tracking unit, equipped with SofTaxic software (EMS srl, Bologna, Italy)
Software suites for advanced signal processing and statistics.

Members

Coordinatore

Franca Tecchio

Publications

Articolo

2019

The Morphology of Somatosensory evoked potentials during middle cerebral artery Aneurysm Clipping: a pilot study

franca tecchio, federico cecconi, luca valci, matteo padalino, elisabetta colamartino

Source: Clinical EEG and neuroscience 2 (2019)., info:cnr-pdr/source/autori:franca tecchio, federico cecconi, luca valci, matteo padalino, elisabetta colamartino/titolo:The Morphology of Somatosensory evoked potentials during middle cerebral artery Aneurysm Clipping: a pilot study/doi:/rivista:Clinical

2017

Electroencephalography-Derived Sensory and Motor Network Topology in Multiple Sclerosis Fatigue

Vecchio, F., Miraglia, Porcaro, C., Cottone, Cancelli, A., Rossini, P.M., Tecchio

Source: Neurorehabilitation and neural repair 31 (2017): 56–64. doi:10.1177/1545968316656055, info:cnr-pdr/source/autori:Vecchio, F. and Miraglia, F. and Porcaro, C. and Cottone, C. and Cancelli, A. and Rossini, P.M. and Tecchio, F./titolo:Electroencephalography-Derived Sensory and Motor Network Topology in Multiple Sclerosis Fatigue/doi:10.1177/1

Simple index of functional connectivity at rest in Multiple Sclerosis fatigue.

Buyukturkoglu, Korhan, Porcaro, Camillo, Cottone, Carlo, Cancelli, Andrea, Inglese, Matilde, Tecchio, Franca

Source: Clinical neurophysiology 128 (2017): 807–813. doi:10.1016/j.clinph.2017.02.010, info:cnr-pdr/source/autori:Buyukturkoglu, Korhan; Porcaro, Camillo; Cottone, Carlo; Cancelli, Andrea; Inglese, Matilde; Tecchio, Franca/titolo:Simple index of functional connectivity at rest in Multiple Sclerosis fatigue./doi:10.1016/j.clinph.2017.02.010/

2016

A simple method for EEG guided transcranial electrical stimulation without models

Cancelli, A., Cottone, C., Tecchio, F., Truong, D.Q., Dmochowski, J., Bikson, M.

Source: Journal of neural engineering (Online) 13 (2016). doi:10.1088/1741-2560/13/3/036022, info:cnr-pdr/source/autori:Cancelli, A. and Cottone, C. and Tecchio, F. and Truong, D.Q. and Dmochowski, J. and Bikson, M./titolo:A simple method for EEG guided transcranial electrical stimulation without models/doi:10.1088/1741-2560/13/3/036022/rivista:J

Biological factors and age-dependence of primary motor cortex experimental plasticity

Polimanti, R., Simonelli, I., Zappasodi, F., Ventriglia, M., Pellicciari, M.C., Benussi, L., Squitti, Rossini, P.M., Tecchio

Source: Neurological sciences (Testo stamp.) 37 (2016): 211–218. doi:10.1007/s10072-015-2388-6, info:cnr-pdr/source/autori:Polimanti, R. and Simonelli, I. and Zappasodi, F. and Ventriglia, M. and Pellicciari, M.C. and Benussi, L. and Squitti, R. and Rossini, P.M. and Tecchio, F./titolo:Biological factors and age-dependence of primary motor cortex ex

Electroencephalographic fractal dimension in healthy ageing and Alzheimer's disease

Smits, F.M., Porcaro, C., Cottone, Cancelli, A., Rossini, P.M., Tecchio, F.

Source: PloS one 11 (2016). doi:10.1371/journal.pone.0149587, info:cnr-pdr/source/autori:Smits, F.M. and Porcaro, C. and Cottone, C. and Cancelli, A. and Rossini, P.M. and Tecchio, F./titolo:Electroencephalographic fractal dimension in healthy ageing and Alzheimer's disease/doi:10.1371/journal.pone.0149587/rivista:P

Neuronal electrical ongoing activity as a signature of cortical areas

Cottone, C., Porcaro, Cancelli, A., Olejarczyk, E., Salustri, Tecchio, F.

Source: Brain structure & function (Internet) (2016): 1–12. doi:10.1007/s00429-016-1328-4, info:cnr-pdr/source/autori:Cottone, C. and Porcaro, C. and Cancelli, A. and Olejarczyk, E. and Salustri, C. and Tecchio, F./titolo:Neuronal electrical ongoing activity as a signature of cortical areas/doi:10.1007/s00429-016-1328-4/rivista:Brain structure

Non-ceruloplasmin copper distinguishes a distinct subtype of alzheimer's disease: A study of eeg-derived brain activity

Tecchio, F., Vecchio, Ventriglia, M., Porcaro, C., Miraglia, Siotto, Rossini, P.M., Rongioletti, Squitti, R.

Source: Current Alzheimer research (Print) 13 (2016): 1374–1384. doi:10.2174/1567205013666160603001131, info:cnr-pdr/source/autori:Tecchio, F. and Vecchio, F. and Ventriglia, M. and Porcaro, C. and Miraglia, F. and Siotto, M. and Rossini, P.M. and Rongioletti, M. and Squitti, R./titolo:Non-ceruloplasmin copper distinguishes a distinct subtype of alzheimer's

2015

Brain plasticity effects of neuromodulation against multiple sclerosis fatigue

Tecchio F., Cancelli A., Cottone C., Ferrucci R., Vergari M., Zito G., Pasqualetti P., Filippi M.M., Ghazaryan A., Lupoi D., Smits F.M., Giordani A., Migliore S., Porcaro C., Salustri C., Rossini P.M., Priori A.

Source: Frontiers in neurology 6 (2015). doi:10.3389/fneur.2015.00141, info:cnr-pdr/source/autori:Tecchio F.; Cancelli A.; Cottone C.; Ferrucci R.; Vergari M.; Zito G.; Pasqualetti P.; Filippi M.M.; Ghazaryan A.; Lupoi D.; Smits F.M.; Giordani A.; Migliore S.; Porcaro C.; Salustri C.; Rossini P.M.; Priori A./titolo:Brain pla

Functional and structural balances of homologous sensorimotor regions in multiple sclerosis fatigue

Cogliati-Dezza, Irene, Zito, Giancarlo, Tomasevic, Leo, Filippi, Maria Maddalena, Ghazaryan, Anna, Porcaro, Camillo, Squitti, Rosanna, Ventriglia, Mariacarla Carla, Lupoi, Domenico, Tecchio, Franca

Source: Journal of neurology (Print) (2015). doi:10.1007/s00415-014-7590-6, info:cnr-pdr/source/autori:Cogliati-Dezza, Irene; Zito, Giancarlo; Tomasevic, Leo; Filippi, Maria Maddalena; Ghazaryan, Anna; Porcaro, Camillo; Squitti, Rosanna; Ventriglia, Mariacarla Carla; Lupoi, Domenico; Tecchio, Franca/titolo:Functional and structur

2014

Contradictory reasoning network: An EEG and fMRI study

Porcaro, Camillo, Medaglia, Maria Teresa, Thai, Ngoc Jade, Seri, Stefano S., Rotshtein, Pia, Tecchio, Franca

Source: PloS one 9 (2014). doi:10.1371/journal.pone.0092835, info:cnr-pdr/source/autori:Porcaro, Camillo; Medaglia, Maria Teresa; Thai, Ngoc Jade; Seri, Stefano S.; Rotshtein, Pia; Tecchio, Franca/titolo:Contradictory reasoning network: An EEG and fMRI study/doi:10.1371/journal.pone.0092835/rivista:PloS one/anno:20

Inter-hemispheric functional connectivity changes with corpus callosum morphology in multiple sclerosis

Zito, G., Luders, E., Tomasevic, L., Lupoi, D., Toga, A. W., Thompson, P. M., Rossini, P. M., Filippi, M. M., Tecchio, F.

Source: Neuroscience 266 (2014): 47–55. doi:10.1016/j.neuroscience.2014.01.039, info:cnr-pdr/source/autori:Zito, G.; Luders, E.; Tomasevic, L.; Lupoi, D.; Toga, A. W.; Thompson, P. M.; Rossini, P. M.; Filippi, M. M.; Tecchio, F./titolo:Inter-hemispheric functional connectivity changes with corpus callosum morphology in multiple scler

The spontaneous fluctuation of the excitability of a single node modulates the internodes connectivity: A TMS-EEG study

Giambattistelli, Federica, Tomasevic, Leo, Pellegrino, Giovanni, Porcaro, Camillo, Melgari, Jean Marc, Rossini, Paolo Maria Aria, Tecchio, Franca

Source: Human brain mapping (Print) 35 (2014): 1740–1749. doi:10.1002/hbm.22288, info:cnr-pdr/source/autori:Giambattistelli, Federica; Tomasevic, Leo; Pellegrino, Giovanni; Porcaro, Camillo; Melgari, Jean Marc; Rossini, Paolo Maria Aria; Tecchio, Franca/titolo:The spontaneous fluctuation of the excitability of a single node modulates

2013

Cortico-muscular coherence as an index of fatigue in multiple sclerosis

Tomasevic, Leo, Zito, Giancarlo, Pasqualetti, Patrizio, Filippi, Maria Maddalena, Landi, Doriana, Ghazaryan, Anna, Lupoi, Domenico, Porcaro, Camillo, Bagnato, Francesca, Rossini, Paolo Maria Aria, Tecchio, Franca

Source: Multiple sclerosis 19 (2013): 334–343. doi:10.1177/1352458512452921, info:cnr-pdr/source/autori:Tomasevic, Leo; Zito, Giancarlo; Pasqualetti, Patrizio; Filippi, Maria Maddalena; Landi, Doriana; Ghazaryan, Anna; Lupoi, Domenico; Porcaro, Camillo; Bagnato, Francesca; Rossini, Paolo Maria Aria; Tecchio, Franca/titolo:Cortico-

Contributo in volume

2014

Semi-blind Functional Source Separation Algorithm from Non-invasive Electrophysiology to Neuroimaging

Camillo Porcaro, Franca Tecchio

Source: Blind Source Separation, edited by Springer Berlin Heidelberg, pp. 521–551, 2014