Sub-cortical sources of the somatosensory pathway are hypoactive in migraine interictally: a Functional Source Separation analysis

Background
Recent morpho-functional evidence pointed out that abnormalities in the thalamus could play a major role in the expression of migraine neurophysiological and clinical correlates. Whether this phenomenon is primary or secondary to its functional disconnection from the brainstem remains to be determined. We used a Functional Source Separation algorithm of EEG signal to extract the activity of the different neuronal pools recruited at different latencies along the somatosensory pathway in interictal migraine without aura (MO) patients.
Methods
Twenty MO patients and 20 healthy volunteers (HV) underwent EEG recording. Four ad-hoc functional constraints, two sub-cortical (FS14 at brainstem and FS16 at thalamic level) and two cortical (FS20 radial and FS22 tangential parietal sources), were used to extract the activity of successive stages of somatosensory information processing in response to the separate left and right median nerve electric stimulation. A band-pass digital filter (450-750 Hz) was applied offline in order to extract high-frequency oscillatory (HFO) activity from the broadband EEG signal.
Results
In both stimulated sides, significant reduced sub-cortical brainstem (FS14) and thalamic (FS16) HFO activations characterized MO patients when compared with HV. No difference emerged in the two cortical HFO activations between the two groups.
Conclusions
Present results are the first neurophysiological evidence supporting the hypothesis that a functional disconnection of the thalamus from the subcortical monoaminergic system may underline the interictal cortical abnormal information processing in migraine. Further studies are needed to investigate the precise directional connectivity across the entire primary subcortical and cortical somatosensory pathway in interictal MO.

Publication type: 
Contributo in atti di convegno
Author or Creator: 
Porcaro, Camillo
Di Lorenzo, Giorgio
Seri, Stefano
Pierelli, Francesco
Tecchio, Franca
Coppola, Gianluca
Publisher: 
Springer Verlag Italia, Milano , Italia
Source: 
1st Joint ANIRCEF-SISC Congress, Rome, Italy, 29-31 October 2015
info:cnr-pdr/source/autori:Porcaro, Camillo; Di Lorenzo, Giorgio; Seri, Stefano; Pierelli, Francesco; Tecchio, Franca; Coppola, Gianluca/congresso_nome:1st Joint ANIRCEF-SISC Congress/congresso_luogo:Rome, Italy/congresso_data:29-31 October 2015/anno:2015
Date: 
2015
Resource Identifier: 
http://www.cnr.it/prodotto/i/366217
https://dx.doi.org/10.1186/1129-2377-16-S1-A55
info:doi:10.1186/1129-2377-16-S1-A55
Language: 
Eng
ISTC Author: 
Franca Tecchio's picture
Real name: 
Camillo Porcaro's picture
Real name: