Reduction in camera-specific variability in [123I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

Purpose Quantitative estimates of dopamine transporter availability,
determined with [123I]FP-CIT SPECT, depend on the
SPECT equipment, including both hardware and
(reconstruction) software, which limits their use in multicentre
research and clinical routine. This study tested a dedicated reconstruction
algorithm for its ability to reduce camera-specific
intersubject variability in [123I]FP-CIT SPECT. The secondary
aim was to evaluate binding in whole brain (excluding striatum)
as a reference for quantitative analysis.
Methods Of 73 healthy subjects from the European Normal
Control Database of [123I]FP-CIT recruited at six centres, 70
aged between 20 and 82 years were included. SPECT images
were reconstructed using the QSPECT software package
which provides fully automated detection of the outer contour
of the head, camera-specific correction for scatter and septal
penetration by transmission-dependent convolution subtraction,
iterative OSEMreconstruction including attenuation correction,
and camera-specific Bto kBq/ml^ calibration. LINK
and HERMES reconstruction were used for head-to-head
comparison. The specific striatal [123I]FP-CIT binding ratio
(SBR) was computed using the Southampton method with
binding in the whole brain, occipital cortex or cerebellum as
the reference. The correlation between SBR and age was used
as the primary quality measure.
Results The fraction of SBR variability explained by age was
highest (1) with QSPECT, independently of the reference region,
and (2) with whole brain as the reference, independently
of the reconstruction algorithm.
Conclusion QSPECT reconstruction appears to be useful for
reduction of camera-specific intersubject variability of
[123I]FP-CIT SPECT in multisite and single-site multicamera
settings. Whole brain excluding striatal binding as the reference
provides more stable quantitative estimates than occipital
or cerebellar binding.

Publication type: 
Author or Creator: 
Buchert R.
Kluge A.
Tossici-Bolt L.
Dickson J.
Bronzel M.
Lange C.
Asenbaum S.
Booij J.
Atay Kapucu L.O.
Svarer C.
Koulibaly P.-M.
Nobili F.
Pagani M.
Sabri O.
Sera T.
Tatsch K.
Vander Borght T.
van Laere K.
Varrone A.
Iida H.
Springer., Heidelberg, Germania
European journal of nuclear medicine and molecular imaging (Internet) (2016): 1–14. doi:10.1007/s00259-016-3309-5
info:cnr-pdr/source/autori:Buchert R.; Kluge A.; Tossici-Bolt L.; Dickson J.; Bronzel M.; Lange C.; Asenbaum S.; Booij J.; Atay Kapucu L.O.; Svarer C.; Koulibaly P.-M.; Nobili F.; Pagani M.; Sabri O.; Sera T.; Tatsch K.; Vander Borght T.; van Laere K.; Va
Resource Identifier:
ISTC Author: 
Marco Pagani's picture
Real name: