Prognostic value of serum copper for post-stroke clinical recovery: A pilot study

The clinical course after ischemic stroke can vary considerably despite similar lesions and clinical status at the onset of symptoms, suggesting that individual factors modulate clinical recovery. Here, we sought to test the working hypothesis that elevated copper values provide prognostic information, and specifically predict worse clinical recovery. We further sought to support previous findings regarding metal metabolism in acute stroke. We assessed total antioxidant status, oxidative stress factors (peroxides) and metal metabolism markers (iron, copper, ceruloplasmin concentration and activity, ferritin, and transferrin) in the acute phase (2-10 days from symptom onset) in 30 patients affected by unilateral middle cerebral artery (MCA) stroke. A longitudinal assessment of clinical deficit was performed in the acute and stabilized phases (typically 6 months post-stroke) using the National Institutes of Health Stroke Scale (NIHSS). In identifying recovery-related factors, we considered effective recovery (ER), calculated as the ratio between actual NIHSS recovery and the total potential recovery. This allows an estimation of the actual recovery adjusted for the patient's initial condition. In the acute phase, clinical severity was correlated with increased peroxide concentrations, and lower iron levels. Less successful clinical recovery was correlated with increased acute copper levels, which entered a multiple regression model that explained 24% of ER variance. These pilot data suggest that, in the acute phase of an ischemic stroke, copper may provide useful information about clinical recovery.

Publication type: 
Articolo
Author or Creator: 
Squitti, Rosanna
Siotto, Mariacristina
Assenza, Giovanni
Giannantoni, Nadia M.
Rongioletti, Mauro
Zappasodi, Filippo
Tecchio, Franca
Publisher: 
Frontiers Research Foundation,, Lausanne , Svizzera
Source: 
Frontiers in neurology 9 (2018). doi:10.3389/fneur.2018.00333
info:cnr-pdr/source/autori:Squitti, Rosanna; Siotto, Mariacristina; Assenza, Giovanni; Giannantoni, Nadia M.; Rongioletti, Mauro; Zappasodi, Filippo; Tecchio, Franca/titolo:Prognostic value of serum copper for post-stroke clinical recovery: A pilot study/
Date: 
2018
Resource Identifier: 
http://www.cnr.it/prodotto/i/395886
https://dx.doi.org/10.3389/fneur.2018.00333
info:doi:10.3389/fneur.2018.00333
http://www.scopus.com/record/display.url?eid=2-s2.0-85047836391&origin=inward
Language: 
Eng
ISTC Author: 
Franca Tecchio's picture
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