Predicting the transition from normal aging to Alzheimer's Disease: a statistical mechanistic evaluation of FDG-PET data

The assessment of the degree of order of brainmetabolism bymeans of a statisticalmechanistic approach applied
to FDG-PET, allowed us to characterize healthy subjects as well as patients with mild cognitive impairment and
Alzheimer's Disease (AD). The intensity signals from 24 volumes of interest were submitted to principal component
analysis (PCA) giving rise to a major first principal component whose eigenvalue was a reliable cumulative
index of order. This index linearly decreased from 77 to 44% going from normal aging to AD patients with intermediate
conditions between these values (r =0.96, p b 0.001). Bootstrap analysis confirmed the statistical significance
of the results.
The progressive detachment of different brain regions from the first component was assessed, allowing for a
purely data driven reconstruction of already known maximally affected areas.
Wedemonstrated for the first time the reliability of a single global index of order in discriminating groups of cognitively
impaired patients with different clinical outcome. The second relevant finding was the identification of
clusters of regions relevant to AD pathology progressively separating fromthe first principal component through
different stages of cognitive impairment, including patients cognitively impaired but not converted to AD. This
paved the way to the quantitative assessment of the functional networking status in individual patients.

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Pagani M
Giuliani A
?berg J
Chincarini A
Morbelli S
Brugnolo A
Arnaldi D
Picco A
Baucknhet A
Buschiazzo A
Sambuceti G
Nobili F
Academic Press,, Orlando, FL , Stati Uniti d'America
NeuroImage (Orlando Fla., Print) 141 (2016): 282–290.
info:cnr-pdr/source/autori:Pagani M, Giuliani A, ?berg J, Chincarini A, Morbelli S, Brugnolo A, Arnaldi D, Picco A, Baucknhet A, Buschiazzo A, Sambuceti G, Nobili F/titolo:Predicting the transition from normal aging to Alzheimer's Disease: a statistical
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