Neurobiological insight into hyperbaric hyperoxia

Aim: Hyperbaric hyperoxia (HBO) is known to modulate aerobic metabolism,
vasoreactivity and blood flow in the brain. Nevertheless, mechanisms
underlying its therapeutic effects, especially in traumatic brain injury (TBI)
and stroke patients, are debated. The present study aimed at investigating
regional cerebral blood flow (rCBF) distribution during acute HBO
Methods: Regional cerebral blood flow response was investigated in seven
healthy subjects exposed to either normobaric normoxia or HBO with
ambient pressure/inspired oxygen pressure of 101/21 and 250/250 kPa
respectively. After 40 min at the desired pressure, they were injected a perfusion
tracer and subsequently underwent brain single photon emission
computed tomography. rCBF distribution changes in the whole brain were
assessed by Statistical Parametric Mapping.
Results: During HBO, an increased relative rCBF distribution was found
in sensory-motor, premotor, visual and posterior cingulate cortices as well
as in superior frontal gyrus, middle/inferior temporal and angular gyrus
and cerebellum, mainly in the dominant hemisphere. During normobaric
normoxia, a higher 99mTc-HMPAO distribution in the right insula and
subcortical structures as well as in bilateral hippocampi and anterior cingulated
cortex was found.
Conclusions: The present study firstly confirmed the rCBF distribution
increase during HBO in sensory-motor and visual cortices, and it showed
for the first time a higher perfusion tracer distribution in areas encompassed
in dorsal attention system and in default mode network. These
findings unfold both the externally directed cognition performance
improvement related to the HBO and the internally directed cognition
states during resting-state conditions, suggesting possible beneficial effects
in TBI and stroke patients.

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Micarelli, Alessandro
Jacobsson, Hans
Larsson, Stig A.
Jonsson, Cathrine E.
Pagani, Marco
Blackwell Publishing,, Oxford , Regno Unito
Acta physiologica (Print) 209 (2013): 69–76. doi:10.1111/apha.12116
info:cnr-pdr/source/autori:Micarelli, Alessandro; Jacobsson, Hans; Larsson, Stig A.; Jonsson, Cathrine E.; Pagani, Marco/titolo:Neurobiological insight into hyperbaric hyperoxia/doi:10.1111/apha.12116/rivista:Acta physiologica (Print)/anno:2013/pagina_da:
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