Functional neuroimaging and clinical features of drug naive patients with de novo Parkinson's disease and probable RBD.

Introduction
The association between Parkinson Disease (PD) and REM sleep behavior disorder (RBD) has been related to a specific, malignant clinical phenotype. Definite RBD diagnosis requires video-polysomnography that is often unfeasible. A malignant clinical PD-RBD phenotype could be expected also in PD patients with probable RBD. Aim of this cross-sectional study was to evaluate whether a more severe neuropsychological and functional neuroimaging phenotype can be identified in PD patients with probable RBD.
Methods
Thirty-eight de novo, drug naïve PD patients underwent a first-line clinical assessment and a second-line multimodal assessment, including neuropsychological evaluation, 123I-FP-CIT-SPECT and 18F-FDG-PET, which were compared between PD patients with (PD + RBD+) and without (PD + RBD-) probable RBD.
Results
On first-line assessment, PD + RBD + patients had significantly more constipation (p = 0.02) and showed worse olfaction (p = 0.01) compared with PD + RBD-while the two groups were similar as for age, presence of orthostatic hypotension, UPDRS-III and MMSE scores. On second-line assessment, PD + RBD + patients showed a worse neuropsychological test profile, more severe nigro-striatal dopaminergic impairment, mainly at caudate level in the less affected hemisphere (p = 0.004) and impaired brain glucose metabolism, with relative hypometabolism in posterior cortical regions and relative hypermetabolism mainly in anterior regions of the more affected hemisphere (p = 0.015).
Conclusions
PD patients with probable RBD are likely to have a more severe neuropsychological and functional brain-imaging phenotype already at the time of diagnosis

Publication type: 
Articolo
Author or Creator: 
Dario Arnaldi
Silvia Morbelli
Andrea Brugnolo
Nicola Girtler
Agnese Picco
Michela Ferrara
Jennifer Accardo
Ambra Buschiazzo
Fabrizio de Carli
Marco Pagani
Flavio Nobili
Publisher: 
Elsevier Science,, Oxford , Regno Unito
Source: 
Parkinsonism & related disorders 29 (2016): 47–53. doi:10.1016/j.parkreldis.2016.05.031
info:cnr-pdr/source/autori:Dario Arnaldi, Silvia Morbelli, Andrea Brugnolo, Nicola Girtler, Agnese Picco, Michela Ferrara, Jennifer Accardo, Ambra Buschiazzo, Fabrizio de Carli, Marco Pagani, Flavio Nobili/titolo:Functional neuroimaging and clinical featu
Date: 
2016
Resource Identifier: 
http://www.cnr.it/prodotto/i/355423
https://dx.doi.org/10.1016/j.parkreldis.2016.05.031
info:doi:10.1016/j.parkreldis.2016.05.031
Language: 
Eng