European multicentre database of healthy controls for [123I]FP- CIT SPECT (ENC-DAT): Age-related effects, gender differences and evaluation of different methods of analysis

Purpose Dopamine transporter (DAT) imaging with [123I]
FP-CIT (DaTSCAN) is an established diagnostic tool in
parkinsonism and dementia. Although qualitative assessment
criteria are available, DAT quantification is important
for research and for completion of a diagnostic evaluation.
One critical aspect of quantification is the availability of
normative data, considering possible age and gender effects
on DAT availability. The aim of the European Normal
Control Database of DaTSCAN (ENC-DAT) study was to
generate a large database of [123I]FP-CIT SPECT scans in
healthy controls.
Methods SPECT data from 139 healthy controls (74
men, 65 women; age range 20-83 years, mean 53 years)
acquired in 13 different centres were included. Images
were reconstructed using the ordered-subset expectationmaximization
algorithm without correction (NOACSC),
with attenuation correction (AC), and with both attenuation
and scatter correction using the triple-energy window
method (ACSC). Region-of-interest analysis was
performed using the BRASS software (caudate and
putamen), and the Southampton method (striatum). The
outcome measure was the specific binding ratio (SBR).
Results A significant effect of age on SBR was found
for all data. Gender had a significant effect on SBR in
the caudate and putamen for the NOACSC and AC
data, and only in the left caudate for the ACSC data
(BRASS method). Significant effects of age and gender
on striatal SBR were observed for all data analysed with
the Southampton method. Overall, there was a significant
age-related decline in SBR of between 4 % and
6.7 % per decade.
Conclusion This study provides a large database of
[123I]FP-CIT SPECT scans in healthy controls across a
wide age range and with balanced gender representation.
Higher DAT availability was found in women than in
men. An average age-related decline in DAT availability
of 5.5 % per decade was found for both genders, in
agreement with previous reports. The data collected in
this study may serve as a reference database for nuclear
medicine centres and for clinical trials using [123I]FPCIT
SPECT as the imaging marker.

Publication type: 
Author or Creator: 
Varrone, Andrea
Dickson, John Caddell
Tossici-Bolt, Livia
Séra, Teréz
Asenbaum, Susanne
Booij, Jan
Kapucu, Özlem Lütfiye
Kluge, Andreas
Knudsen, Gitte Moos
Koulibaly, Pierre Malick
Nobili, Flavio Mariano
Pagani, Marco
Sabri, Osama
Vander Borght, Thierry M.
Van Laere, Koen Van R
Tatsch, Klaus
Springer., Heidelberg;, Germania
European journal of nuclear medicine and molecular imaging (Print) 40 (2013): 213–227. doi:10.1007/s00259-012-2276-8
info:cnr-pdr/source/autori:Varrone, Andrea; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Booij, Jan; Kapucu, Özlem Lütfiye; Kluge, Andreas; Knudsen, Gitte Moos; Koulibaly, Pierre Malick; Nobili, Flavio Mariano; Pagani, Marco
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