Erratum to: Automatic semi-quantification of [123I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database

Purpose The aim of this study was to assess striatal dopamine
transporter (DAT) availability in a large group of
normal subjects.
Methods The study included 122 healthy subjects, aged 18-
83 years, recruited in the multicentre 'ENC-DAT' study
(promoted by the European Association of Nuclear Medicine).
Brain single photon emission computed tomography
(SPECT) was acquired by means of dual-head cameras 3 h
after [123I]FP-CIT administration. Specific to nondisplaceable
binding ratios (SBRs) in the basal ganglia were computed
using the 'BasGan' software, allowing automatic
value extraction with partial volume effect correction. Multicentre
camera inhomogeneity was taken into account by
calibrating values on basal ganglia phantom data. SBR in
each caudate nucleus (C) and putamen (P) were the dependent
variables in a repeated measures general linear model
analysis; age, gender, handedness and body mass index
(BMI) were the independent variables.
Results SBR values in C and P were significantly associated
with age (mean rate decrease with age: 0.0306 per year, or
0.57 % of the general mean; p<0.0001) and gender (women
had higher values; p00.015), while no significant effect was
found for handedness and BMI. A significant interaction
was found between age and region (p<0.0001) as the agerelated
decline was 0.028 for left C, 0.026 for right C and
0.034 for both P. P/C ratio analysis confirmed that agerelated
SBR decrease was stronger in P than in C (p<
0.0001). No significant effect was found for season or time
of the day when the scan was acquired by analysing the
residual of SBR values in C and P, after subtraction of age
and gender effects.
Conclusion This study confirms the dependency of DAT on
ageing and highlights the gender differences in a large
sample of healthy subjects, while it does not support the
dependency of DAT on BMI, handedness, circadian rhythm
or season.

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Nobili, Flavio Mariano
Naseri, Mehrdad
De Carli, Fabrizio
Asenbaum, Susan
Booij, Jan
Darcourt, Jacques
Ell, Peter Joseph
Kapucu, Özlem Lütfiye
Kemp, Paul M.
Svarer, Claus
Morbelli, Silvia D.
Pagani, Marco
Sabri, Osama
Tatsch, Klaus
Tossici-Bolt, Livia
Séra, Teréz
Borght, Tierry Vander
Van Laere, Koen Van R
Varrone, Andrea
Springer., Heidelberg;, Germania
European journal of nuclear medicine and molecular imaging (Print) 40 (2013): 565–573. doi:10.1007/s00259-013-2337-7
info:cnr-pdr/source/autori:Nobili, Flavio Mariano; Naseri, Mehrdad; De Carli, Fabrizio; Asenbaum, Susan; Booij, Jan; Darcourt, Jacques; Ell, Peter Joseph; Kapucu, Özlem Lütfiye; Kemp, Paul M.; Svarer, Claus; Morbelli, Silvia D.; Pagani, Marco; Sabri, Osam
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