Correlation between Apolipoprotein E genotype and brain metabolism in amyotrophic lateral sclerosis

Background and purpose: The aim of the study was to evaluate the metabolic
correlates of Apolipoprotein E (APOE) genotype in amyotrophic lateral sclerosis
(ALS) and to investigate the role of e2 as a risk factor for cognitive impairment.
Methods: A total of 159 ALS cases underwent APOE and ALS-related genes
analysis, neuropsychological assessment and cerebral 18F-2-fluoro-2-deoxy-Dglucose
positron emission tomography. The APOE genotype was regressed
against whole brain metabolism as assessed by 18F-2-fluoro-2-deoxy-D-glucose
positron emission tomography, with age, sex, education, type of onset and
C9orf72 status as covariates.
Results: Brain metabolism was significantly positively correlated with APOE
genotype from e2/e2 to e3/e4 in the left prefrontal [Brodmann area (BA) 10],
orbitofrontal (BAs 11, 45, 47) and anterior cingulate (BA 32) cortices. There
was a tendency to a relative hypometabolism going towards the e2/e2 extreme.
Conclusions: We found a highly significant, relatively lower metabolism in
association with the e2 allele in extra-motor areas typically affected in frontotemporal
dementia (left prefrontal, orbitofrontal and anterior cingulate cortices),
strengthening the finding of a role of e2 as a risk factor for cognitive
impairment in ALS. Our data suggested a link between cholesterol homeostasis
and neurodegeneration.

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Canosa A
Pagani M
Brunetti M
Barberis M
Iazzolino B
Ilardi A
Cammarosano S
Manera U
Moglia C
Calvo A
Cistaro A
Chiò A
Blackwell Science., [Oxford], Regno Unito
European journal of neurology (Online) 26 (2019): 306–312. doi:10.1111/ene.13812
info:cnr-pdr/source/autori:Canosa A, Pagani M, Brunetti M, Barberis M, Iazzolino B , Ilardi A, Cammarosano S, Manera U, Moglia C, Calvo A, Cistaro A, Chiò A/titolo:Correlation between Apolipoprotein E genotype and brain metabolism in amyotrophic latera
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