People with epilepsy have a high risk of comorbid diseases, including depression. Nevertheless, depression is often poorly recognized and inadequately treated, with negative consequences on patients' quality of life and the risk of suicide. This review of literature aims to present the most interesting results regarding the prevalence of depression in people with epilepsy, the complexity of causes, diagnosis and treatment. The results show that depression is one of the most common disorders in epilepsy patients, but the diagnosis is complex, as the effects of the crisis on emotion regulation and mood states can be confused with depressive symptoms. Accordingly, particularly important is the use of appropriate diagnostic tools. The literature reviewed suggests the following causes: the side effects of anticonvulsants; some neurological elements (type, frequency, severity of the crises) and some psychosocial issues (stigma, impact of stressful events of the epileptic condition, recurrent crisis experienced as unforeseeable and uncontrollable events). The importance of psychosocial issues has emerged in many studies, as well as the need for interventions aimed at acquiring cognitive, behavioral and social skills useful for dealing positively with the disease. Traditionally, the management of depression in epilepsy has involved drug treatments, but recently the opinions in this regard are discordant. Instead, numerous studies have highlighted the effectiveness of cognitive-behavioral psychotherapy. Antidepressants are especially recommended for those at risk of suicide. Since epilepsy is mainly treated by neurologists, it is important for them to pay attention to their patients' psychological conditions, and to cooperate with psychologists and psychotherapists.
