The Alzheimer's disease metabolic brain pattern in mild cognitive impairment.

We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in 18F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of 18F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression

Publication type: 
Articolo
Author or Creator: 
Sanne K Meles
Marco Pagani
Dario Arnaldi
Fabrizio De Carli
Barbara Dessi
Silvia Morbelli
Gianmario Sambuceti
Cathrine Jonsson
Klaus L Leenders
Flavio Nobili
Publisher: 
Raven Press,, New York, N.Y. , Stati Uniti d'America
Source: 
Journal of cerebral blood flow and metabolism 37 (2017): 3643–3648. doi:10.1177/0271678X17732508
info:cnr-pdr/source/autori:Sanne K Meles, Marco Pagani, Dario Arnaldi, Fabrizio De Carli, Barbara Dessi, Silvia Morbelli, Gianmario Sambuceti, Cathrine Jonsson, Klaus L Leenders, and Flavio Nobili/titolo:The Alzheimer's disease metabolic brain pattern in
Date: 
2017
Resource Identifier: 
http://www.cnr.it/prodotto/i/375764
https://dx.doi.org/10.1177/0271678X17732508
info:doi:10.1177/0271678X17732508
Language: 
Eng